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TNF alpha antibody
TNF alpha
Reactivity: Human
WB, EIA, RIA
Host: Mouse
Monoclonal
tnfa9-9
unconjugated
Product Details anti-TNF alpha Antibody
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Target
See all TNF alpha Antibodies
TNF alpha
(Tumor Necrosis Factor alpha (TNF alpha))
Reactivity
All reactivities for TNF alpha antibodies
Human
Host
All hosts for TNF alpha antibodies
Mouse
Clonality
All clonalities for TNF alpha antibodies
Monoclonal
Conjugate
All conjugates for TNF alpha antibodies
This TNF alpha antibody is un-conjugated
Application
All applications for TNF alpha antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA), Radioimmunoassay (RIA)
Characteristics
Synonyms: TNF, TNF-a, TNFA, TNFSF2, Cachectin, Tumor necrosis factor ligand superfamily member 2
Purification
Protein A Chromatography
Immunogen
Human tumor necrosis factor a
Clone
Tnfa9-9
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
ELISA. RIA. Western blot. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Reconstitution
Restore in aqua bidest to 1 mg/mL.
Buffer
50 mM TRIS, pH 7,4, 0.02 % Sodium Azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store lyophilized at 2 - 8 °C and reconstituted at -20 °C. Avoid repeated freezing andthawing. Shelf life: One year from despatch.
Expiry Date
12 months
Target Details for TNF alpha
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Target
TNF alpha
(Tumor Necrosis Factor alpha (TNF alpha))
Alternative Name
Tumor Necrosis Factor (TNF-Alpha) (TNF alpha Products )
Synonyms
DIF antibody, TNF-alpha antibody, TNFA antibody, TNFSF2 antibody, RATTNF antibody, Tnfa antibody, tnf antibody, TNF-a antibody, TNFalpha antibody, Tnfsf1a antibody, TNFa antibody, cTNF antibody, Tnf-alpha antibody, tnfa-like antibody, TNF-ALPHA antibody, dif antibody, tnfa antibody, xtnf antibody, tnfsf2 antibody, tnf-alpha antibody, Cachectin antibody, tumor necrosis factor antibody, tumor necrosis factor b (TNF superfamily, member 2) antibody, tumor necrosis factor alpha antibody, tumor necrosis factor a (TNF superfamily, member 2) antibody, TNF antibody, Tnf antibody, tnf antibody, tnfb antibody, tnf-alpha antibody, LOC103694380 antibody, tnfa antibody
Background
Tumor Necrosis Factor (TNF) is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. TNF is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.Synonyms: Cachectin, TNF, TNF-a, TNFA, TNFSF2, Tumor necrosis factor ligand superfamily member 2
UniProt
P01375
Pathways
NF-kappaB Signaling , Apoptosis , Caspase Cascade in Apoptosis , TLR Signaling , Cellular Response to Molecule of Bacterial Origin , Regulation of Leukocyte Mediated Immunity , Positive Regulation of Immune Effector Process , Production of Molecular Mediator of Immune Response , Positive Regulation of Endopeptidase Activity , Hepatitis C , Protein targeting to Nucleus , Inflammasome
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